The 100 ml vial is restricted to adults, adolescents, and children weighing more than 33 kg. Dosing based on patient weight.
The minimum interval between each administration must be at least 4 hours. No more than 4 doses to be given in 24 hours.
Renal impairment:
The minimum interval between each administration in patients with severe renal impairment must be at least 6 hours.